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Lymphoblastic Lymphoma

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Lymphoblastic lymphoma is a form of lymphoma which occurs mainly in children and adolescents, where it accounts for about half of childhood lymphomas. About two-thirds of the patients are males. A second peak is seen again in patients over 40 years of age.
 
Under the newest WHO lymphoma classification, lymphoblastic lymphoma is either determined to be a precursor T cell neoplasm or a precursor B cell neoplasm depending on the type of lymphatic cells that are cancerous.
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The distinction from acute lymphoblastic leukemia is in part arbitrary, based on the degree of marrow involvement. The chief biologic difference is that lymphoblastic leukemias are predominantly B-cell diseases, unlike the extra-medullary, mostly T-cell lymphoblastic lymphomas.

Childhood

Lymphoblastic lymphoma makes up about 30% of childhood lymphomas. With intensive chemotherapy, long-term disease-free survival may be attained, and the childhood complete remission rate is as high as 96%.

A majority of patients have tumors above the diaphragm - abdominal involvement is uncommon.

Combined chemotherapy is standard treatment with the specific type dependent on the stage of the disease.   NCI recommends all children be generally considered for clinical trials and be cared for by a multidisciplinary team of pediatric oncologists.

Childhood Reference:

Personal Stories

  • Bryce's Story - a former preschooler who conquered lymphoblastic lymphoma, recommended (updated link)
  • Bobby McQuin is a lymphoblastic leukemia survivor (new)
  • Megan Young is a courageous young girl battling LBL

Further Reading / In-Depth

Non-Hodgkin's Lymphomas, Peter M. Mauch (Editor), James O. Armitage (Editor), et al., 2004.

  • Section IV: Pathology, Biology, Clinical Evaluation, and Treatment Section
    • Chapter 31: Precursor B- and T-Cell Lymphoblastic Lymphoma

Multimedia (in conjunction with Healthology) (new)

Information Sources

Technical Information


Non-Hodgkin's Lymphoma Information Pages:

    Non-Hodgkin's Lymphomas
    Non-Hodgkin's Lymphoma: Diagnosis
    Non-Hodgkin's Lymphoma: Aggressive Lymphomas
    Non-Hodgkin's Lymphoma: Indolent Lymphomas
    Non-Hodgkin's Lymphoma: Treatment
    Non-Hodgkin's Lymphoma: Resources
    Bone Marrow and Stem Cell Transplants

Childhood Lymphoma Information Pages

    Childhood Lymphoma
    Childhood Non-Hodgkin's Lymphoma
    Childhood Non-Hodgkin's Lymphoma: Diagnosis
    Childhood Non-Hodgkin's Lymphoma: Types and Staging
    Childhood Non-Hodgkin's Lymphoma: Treatment
    Childhood Lymphoma: Resources

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This page is a work in progress - if you have more complete information, references, or other information please contact the author. The author is not in the medical field and does not warrant the correctness of the material on this page or the sites linked - please take online information and consult with your own medical team to make informed decisions.

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Updated October 30, 2005