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Site Navigation		Extranodal NK or T Cell Lymphoma - Nasal

The extranodal nasal NK or T Cell lymphomas are rare forms of lymphoma. Nasal-type T/NK-cell lymphomas are common in Asia and in parts of Latin America but rare in the United States and in Europe. This may reflect an ethnic predisposition for the disease. Children may be effected as well as adults. Most studies have shown a male-to-female ratio of 2:1 to 3:1 NK or T cell nasal lymphomas represent about 75% of all nasal lymphomas, the rest being B-cell lymphoma. Tumors are most common in the nasal cavity but other sites may include the skin, gastrointestinal tract, testis, kidney, upper respiratory tract and rarely the eye/orbit. Commonly patients present with a nasal mass with bleeding and local bony destruction. Rarely they may present with skin ulcer or GI perforation if these sites are primarily involved. About 10-20% of patients presenting with nasal NK/T-cell lymphoma may also have skin involvement at same time.		<! browsers dont understand iframe show this > <p align="right">:-)</p>
The course of the disease is usually aggressive, with a large number of Asian studies reporting a median survival of 6 to 25 months. Several American and European studies have shown similar results.	<! browsers dont understand iframe show this > <p align="right">:-)</p>

The cause, like in many lymphomas, is unclear but it appears to be related to the Epstein-Barr virus. Treatment: The prognosis of extranodal NK/T-cell lymphoma is variable. Some patients respond well to chemotherapy such as CHOP combined with local radiation, achieving complete remission and others perish with disseminated disease despite aggressive therapy. Some have suggested use of daunorubicin chemotherapy or integration of L-asparaginase into therapy. Transplants also appear to have some promise in treatment. Since this cancer is so rare, your medical team will most likely search the current medical literature such as PubMed for the latest successful treatment strategies. Below are two example abstracts on treatments used from the literature: Abstract: Early stage nasal NK/T-cell lymphoma: clinical outcome, prognostic factors, and the effect of treatment modality. Cheung MM et al., Int J Radiat Oncol Biol Phys. 2002 Sep 1; 54(1): 182-90 Abstract: Successful Treatment of Disseminated Nasal NK/T-Cell Lymphoma Using Double Autologous Peripheral Blood Stem Cell Transplantation, Makoto Sasaki et al. International Journal of Hematology Case Report VOL 71-1.P75 Abstract: Therapeutic outcome of extranodal NK/T-cell lymphoma initially treated with chemotherapy--result of chemotherapy in NK/T-cell lymphoma. Kim BS et al. Acta Oncol. 2003; 42(7): 779-83 Further Reading / In-Depth Non-Hodgkin's Lymphomas, Peter M. Mauch (Editor), James O. Armitage (Editor), et al., 2004. Section IV: Pathology, Biology, Clinical Evaluation, and Treatment Section Chapter 26: Mature Nodal and Extranodal T-Cell and Non-Hodgkin's Cell Lymphomas (including Nasal Natural Killer/T-Cell Lymphoma) Excellent but Technical: An Illustrated Guide to Skin Lymphomas, Cerroni, Gatter, Kerl, 2nd. Ed, 2005 Chapter 6: Other Cutaneous Cytotoxic Lymphomas Extranodal NK/T-Cell Lymphoma, Nasal Type pp. 73-75 Web Resources: Paper on NK Cell Lymphoma by Kazuo Oghimi, International Journal of Hematology, August 2002 References: Paper on NK Cell Lymphoma by Kazuo Oghimi, International Journal of Hematology, August 2002 Paper Final Diagnosis -- Extranodal NK/T-cell Lymphoma, Nasal Type by Zhengbin Lu, MD Paper Final Diagnosis -- Nasal-Type T/NK-Cell Lymphomas by Melissa Halpern, MD Papers: Jaffe ES, Harris NL et al. WHO Classification of tumors, Tumors of Hematopoietic and lymphoid tissues, IARC Press, 2001, Chapter 7, 204-207 Barnes L, Swerdlow S. Surgical Pathology of the Head and Neck, 2001, Marcel Dekker, Inc. New York, Vol 2, Chapter 18, 1307-1312, Greer GP, Kinney MC et al, T cell and NK cell lymphoproliferative disorders, Hematology, American Society of Hematology, 2001 Yong W, Zheng W et al, Clinical characteristics and treatment of midline nasal and nasal type NK/T-cell lymphoma, Zhonghua Yi Xue Za Zhi 2001 July; 81(13): 773-5 Cheung MM, Chan JK et al, Primary non-Hodgkin's lymphoma of the nose and nasopharynx: clinical features, tumor immunophenotype, and treatment outcome in 113 patients. J. Clin Oncol 16:70-77. Non-Hodgkin's Lymphoma Information Pages: Non-Hodgkin's Lymphomas Non-Hodgkin's Lymphoma: Diagnosis Non-Hodgkin's Lymphoma: Aggressive Lymphomas Non-Hodgkin's Lymphoma: Indolent Lymphomas Non-Hodgkin's Lymphoma: Treatment Non-Hodgkin's Lymphoma: Resources Bone Marrow and Stem Cell Transplants Childhood Lymphoma Information Pages: Childhood Lymphoma Childhood Non-Hodgkin's Lymphoma Childhood Non-Hodgkin's Lymphoma: Diagnosis Childhood Non-Hodgkin's Lymphoma: Types and Staging Childhood Non-Hodgkin's Lymphoma: Treatment Childhood Lymphoma: Resources Home - Gateway to Support and More The Lymphoma Information Network This page is a work in progress - if you have more complete information, references, or other information please contact the author. The author is not in the medical field and does not warrant the correctness of the material on this page or the sites linked - please take online information and consult with your own medical team to make informed decisions. Copyright � 2004-2005 Lymphoma Information Network - All Rights Reserved http://www.LymphomaInfo.net/ Updated October 30, 2005

Extranodal NK or T Cell Lymphoma - Nasal

Further Reading / In-Depth