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| Site Navigation | Nodal Marginal Zone Lymphoma |
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| Nodal Marginal zone lymphomas
(NMZL) is an indolent B-cell
lymphoma confined primarily in lymph nodes. It is rare, only
comprising 1 to 3% of all Non-Hodgkin's lymphomas. Marginal Zone
lymphomas in the spleen and in mucosa
lymphoid tissue (MALT) are now considered separate entities under the
newer WHO classification system. Presentation Many patients can have their cancer diagnosed with stage I or stage II disease although it is first diagnosed at all stages. Nodal marginal zone lymphomas are slightly more aggressive diseases compared to MALT lymphomas, tending to present at a higher stage. |
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The disease has been seen in patients with and without Hepatitis C
infection. It appears that a gene rearrangement may be the cause of
this form of NHL although studies in this area are continuing. |
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Treatment Localized involvement can be treated with radiation or surgery. The chemotherapy drugs chlorambucil or fludarabine have been used to treat NMCL also. Given the rarity of this form of lymphoma along with recent study of NMZL as a distinct NHL entity, you should consult your doctor who will search current literature for the best treatment options. Further Reading / In-Depth
Web Resources:
References: (new)
Non-Hodgkin's Lymphoma Information Pages: Non-Hodgkin's
Lymphomas Other Pages of Interest: This page is a work in progress - if you have more complete information, references, or other information please contact the author. The author is not in the medical field and does not warrant the correctness of the material on this page or the sites linked - please take online information and consult with your own medical team to make informed decisions. Copyright © 1998-2005 Lymphoma Information
Network - All Rights Reserved |
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