Nodal Marginal Zone Lymphoma (NMZL) is an indolent B-cell lymphoma that is found mostly in the lymph nodes. The disease is rare and only accounts for 1% of all Non-Hodgkin’s Lymphomas (NHL). It is most commonly diagnosed in older patients, with women more susceptible than men.
The disease is classified as a marginal zone lymphoma because the mutation occurs in the marginal zone of the B-cells. Due to its confinement in the lymph nodes, this disease is also classified as nodal.
Diagnosis is made using a lymph node biopsy. Other tests, such as X-rays, CT scan, PET scan, ultrasound, and bone marrow biopsy are used to stage the disease. Staging is as follows:
Most patients are diagnosed in the earlier stages of disease.
As this is a very slow growing disease, the "Watch and Wait" method may be employed for patients who don’t have many symptoms. Other treatment include: