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Stanford V is a chemotherapy regimen currently in clinical trials at Stanford Medical Center for Hodgkin's Lymphoma / Disease. Seven different chemotherapy drugs are administered over a shorter period of time, but more frequently, than standard chemotherapy regimens such as MOPP or ABVD. It is believed that this regimen will prove to be at least as effective as ABVD, while being better tolerated and having fewer long term side effects.

The drugs in the regimen:

Mechlorethamine (Mustargen) by vein once every 4 weeks
Doxorubicin (Adriamycin) by vein every odd week
Vinblastine (Velban) by vein every odd week
Vincristine (Oncovin) by vein every even week
Bleomycin (Blenoxane) by vein every even week
Etoposide (VP-16) by vein 2 days in a row weeks 3, 7, 11
Prednisone by mouth every other day

There are also other drugs prescribed to help with side effects and to prevent mouth sores and infection.

Effectiveness:

In trials from May 1989 to August 1995, 94 previously untreated patients with Hodgkin's disease (28 stage II bulky disease, and 66 stage III or IV) received Stanford V chemotherapy for 12 weeks with and without radiation therapy. With a median follow-up of 3 years, the actuarial 6-year survival was 93% and the freedom from progression 89%. There had been no relapses or deaths among the 28 patients with stage II bulky mediastinal disease. Eight relapses and three deaths occurred in the group of 66 patients with stage III-IV disease. Lower cumulative exposure to alkylating agents, doxorubicin, bleomycin and limited use of radiation is expected to improved the prospects for fertility and decrease the risks for secondary cancers and heart problems.

Side Effects:

See information on individual chemotherapy agents for side effects. Again the trial organizers hope that side effects are reduced compared to ABVD.

Study Center(s):

Stanford University Medical Center
- Current Study (1/2004)
- Stanford Hospital and Clinics

Links for more information on Stanford V:

NCBI PubMed: J Clin Oncol 2002 Feb 1;20(3):607-9 Horning SJ et al. Stanford V and radiotherapy for locally extensive and advanced Hodgkin's disease: mature results of a prospective clinical trial
Mike Lach's Stanford V Page (link updated 12-04)
Li's Pages - Stanford V

Experiences

Mike Lach's Hodgkins Page (link updated 12-04)
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Books on Lymphoma Treatment including chemotherapy

For more information on Adult Hodgkin's Disease, please see the following pages: :

Other pages you may want to visit:

Lymphoma Information Network

Childhood Hodgkin's Disease Information Pages

This page is a work in progress - if you have more complete information, references, or other information please contact the author. The author is not in the medical field and does not warrant the correctness of the material on this page or the sites linked - please take online information and consult with your own medical team to make informed decisions.

Hodgkin's Chemotherapy: Stanford V