One of the biggest blows to my whole lifestyle, both before and after chemo for lymphoma, was the fatigue (loss of energy). Sure, during chemo was the worst, with some days I was barely able to drag my butt out of bed. My wife was pregnant with our second at the time. The first time she thought she was having the baby I told her I couldn't make it I was so bad. Fortunately it was a false alarm and she was born the next week (my off chemo weekend) when I was able to get about.